First-time clinical data for ASG-15ME and ASG-22ME (Enfortumab vedotin) were presented today at the American Society of Clinical Oncology (ASCO) 51st Annual Meeting being held June 3-7, 2016 in Chicago, IL.
ASG-15ME and ASG-22ME are investigational antibody-drug conjugates (ADCs) consisting of monoclonal antibodies designed to deliver microtubule-disrupting agents selectively to tumor cells. This approach is intended to spare non-targeted cells and thus reduce many of the toxic effects of traditional chemotherapy while enhancing antitumor activity.
ASG-15ME targets SLITRK6 and ASG-22ME targets Nectin-4. These proteins are highly expressed in urothelial cancers, particularly bladder cancer. Under the collaboration, the companies are co-developing and plan to globally co-commercialize ASG-15ME and ASG-22ME.
ASG-15ME is an investigational antibody-drug conjugate (ADC) composed of an anti-SLITRK6 monoclonal antibody attached to a microtubule-disrupting agent, monomethyl auristatin E (MMAE), using Seattle Genetics proprietary, industry-leading linker technology. ASG-15ME is the first and only agent to target SLITRK6, a transmembrane protein identified as an ADC target by Agensys, which is expressed on many solid tumors.
Preclinical data demonstrate that ASG-15ME effectively binds to target cells, internalizes and induces cell-killing activity.
ASG-22ME is an investigational ADC composed of an anti-Nectin-4 monoclonal antibody attached to a microtubule-disrupting agent, Monomethyl-Auristatin E, also known as MMAE, using Seattle Genetics proprietary, industry-leading linker technology. ASG-22ME is the first and only agent to target Nectin-4, a cell adhesion molecule identified as an ADC target by Agensys, which is expressed on many solid tumors. Preclinical data demonstrate that ASG-22ME effectively binds to target cells, internalizes and induces cell-killing activity.
Read the full article on ADC Review / Journal of Antibody-drug Conjugates.
Last editorial review: June 6, 2016.
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