Wiping out Metastasizing Cancer

Biomedical engineers at Cornell University inIthaca in New York, NY have discovered a new way to destroy metastasizing cancer cells traveling through the bloodstream by hitching cancer-killing proteins along for a ride on life-saving white blood cells. In this illustration: the Natural?Killer?Cells?concept:?nanoscale?liposomes?with?TRAIL?protein?(in?green)?attach?to?the?surface?of?white?blood?cells,?and?are?available?in?the?blood?flow?to?bump?into?cancer?cells?and?program?them?to?die. Photo: Michael King,Ph.D, professor of biomedical engineering Cornell University, [1][2][3]

Illustration 1: E-selectin/TRAIL?liposomes?attach?to?the?surface?of?leukocytes?in?the?blood,?and?then?induce?cancer?cell?death?through?surface?contact.  The schematic shows the two-step mechanism involving decoration of leukocytes with liposomes (A), which then contact circulating cancer cells and activate the death receptor (B).

For more information:
[1] Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR. TRAIL-Coated Leukocytes that Kill Cancer Cells in the Circulation. Proc Natl Acad Sci U S A. 2014, January. [Article]
[2] Rana K, Liesveld JL, King MR. Delivery of apoptotic signal to rolling cancer cells: a novel biomimetic technique using immobilized TRAIL and E-selectin.Biotechnol Bioeng. 2009 Apr 15;102(6):1692-702. doi: 10.1002/bit.22204.[Article][PubMed]
[3] New Approach of Piggy-backing Proteins may help Wipe Out Metastasizing Cancer – Onco’Zine – The International Oncology Network. January 6, 2014 [Article]

Illustrations: Melissa Osgood, Cornell University inIthaca in New York, NY. Courtesy: Cornell University inIthaca in New York, NY.

Copyright ? 2013 InPress Media Group/Sunvalley Communication. All rights reserved. Republication or redistribution of InPress Media Group/Sunvalley Communication content, including by framing or similar means, is expressly prohibited without the prior written consent of InPress Media Group/Sunvalley Communication. InPress Media Group/Sunvalley Communication shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Onco’Zine and Oncozine are registered trademarks and trademarks of Sunvalley Communication around the world.