During the upcoming annual meeting of the American Association for Cancer Research (AACR), scheduled to be held April 25-30, 2025 in Chicago, Illinois, experts from The Ohio State University Comprehensive Cancer Center will present new findings in areas ranging from targeted therapies for breast cancer, endometrial cancers, lung cancer, survivorship
, and other research topics.
Scheduled topics and presentations include planned and late-breaking presentations.
Breast Cancer
- Epigenetic age in normal breast tissues and its association with breast cancer risk factors- LATE-BREAKING – Expert: Min-Ae Song (LB307/Poster #4)(Session Title: Late-Breaking Research: Molecular/Cellular Biology and Genetics 2) Tuesday, April 29, 09.00 pm – 12.00 pm.
- Enhancing chemotherapeutic activity against triple-negative breast cancer cells using induced electric fields Expert: Eswar Shankar/Gautam Saeathy (Poster #6)(Session Title: Regulation of Gene Expression in Drug Resistance) Tuesday, April 29, 09.00 pm – 12.00 pm.
New Molecular Targets and Novel Treatment Options
- The 31-gene expression profile identifies patients at risk of developing early distant metastases and can guide risk-appropriate surveillance strategies – Expert: Merve Hasanov, MD (Poster #14)(Session Title: Prognostic Biomarkers 2) Monday, April 28, 02.00 pm – 05.00 pm
- Evaluating TRAP1 as a novel, potential therapeutic target in dedifferentiated liposarcoma- LATE-BREAKING – Expert: Roma Karna / Federica Calore, PhD (Poster #13)(Session Title: Prognostic Biomarkers 2) Tuesday, April 29, 09.00 am – 12.00 pm
- An open-label phase 1 study to investigate JBZ001 in adults with advanced solid tumors and non-Hodjkin lymphoma (JBZ001, Trial in Progress)-LATE-BREAKING -Expert: Asrar Alahmadi (Poster #16)(Session Title: Phase I Clinical Trials in Progress 2) Tuesday, April 29, 09.00 am – 12.00 pm
- Deciphering PSMA7 modulation by RT and TMZ for enhanced GBM treatments – Expert: Christian Showalter, Ph.D (Poster #4)(Session Title: Radiation Science 1) Monday, April 28, 09.00 am – 12.00 pm
- A novel small molecule inhibitor, HO-4200, modulates macrophage polarization and suppresses MDSCs to enhance antitumor immune responses in ovarian cancer – Expert: Ganesh Yadaigiri (Poster #24)(Session Title: Novel Antitumor Agents 1) Monday, April 28, 09.00 am – 12.00 pm
Obesity and Lifestyle
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- Impact of body composition on tumor proteomics and survival outcomes in clear cell renal cell carcinoma – Expert: Cuthbert M Mahenge, MD, MPH (Poster #13)(Session Title: Health Disparities and Systemic Inequities: Lifestyle, Metabolism, and Disparities in Cancer Risk and Outcomes) Tuesday, April 29, 02.00 pm – 05.00 pm.
- Metformin induces cell cycle arrest and inhibits proliferation in KRAS-mutated colorectal cancer – Expert: Holli Ann Loomans-Kropp, PhD. (Poster #9)(Session Title: Development of Chemopreventive Agents and Preclinical Models) Tuesday, April 29, 02.00 pm – 05.00 pm.
- Body size and composition in relation to PI3K/AKT/mTOR signaling: insights into cancer risk and outcomes – a systematic review – Expert: Rand Lucine Akasheh, PhD. (Poster #2)(Session Title: Socioeconomic, Lifestyle, and Biological Drivers of Cancer Risk and Survival: Clinical Outcomes and Treatment Guidelines) Wednesday, April 30, 09.00 am – 12.00 pm.
- The BE FIT study: feasibility of an exercise intervention on the microbiome and immune function in a high-risk cohort for lung cancer. Expert: Marisa A. Bittoni, PhD, MS (Poster #5)(Session Title: The Role of Physical Activity, Diet, Microbiome, Obesity, and Energy Balance in the Cancer Continuum) Monday, April 28, 02.00 pm – 05.00 pm
- Extracellular vesicle dynamics in alternate-day fasting combined with low-carbohydrate weight loss intervention. Expert: Faiza Kalam, PhD (Poster #4)(Session Title: The Role of Physical Activity, Diet, Microbiome, Obesity, and Energy Balance in the Cancer Continuum) Monday, April 28, 02:00 pm – 05:00 pm
Cancer Prevention and Survivorship
- Systemic chronic inflammation is associated with quality of life in the Cancer Disparities Research Network – Expert: Holli Ann Loomans-Kropp, PhD (Poster #17)(Session Title: Innovations in Prevention and Cancer Care: Addressing Disparities, Inflammation, Survivorship, and Modifiable Risk Factors) Wednesday, April 30, 09:00 am – 12:00 pm.
Featured Image licensed under the Unsplash+ License.
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