For the first time researchers at the Institute for Aging Research at the Albert Einstein College of Medicinein Bronx, N.Y. have shown a causal evidence linking visceral fat, fat stored deep in the abdominal cavity, directly to an increased risk for colorectal cancer. Their research also suggest that factors other than known metabolic mediators, may impact tumor development. The data furthermore emphasizes that strategies designed to deplete visceral fat stores in humans should be considered in the prevention of intestinal cancer

The results from the mouse study were published in Cancer Prevention Research, a journal of the American Association for Cancer Research (AACR).

Commenting on the study, Derek M. Huffman, Ph.D. a postdoctoral fellow at the Institute for Aging Research at the Albert Einstein College of Medicine, said ?There has been some skepticism as to whether obesity per se is a bona fide cancer risk factor, rather than the habits that fuel it, including a poor diet and a sedentary lifestyle,?

Huffman further noted ?Although those other lifestyle choices play a role, this study unequivocally demonstrates that visceral adiposity is causally linked to intestinal cancer.?

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Obesity increases risk
Prior research has shown that obesity markedly increases the likelihood of being diagnosed with and dying from many cancers. Huffman and colleagues sought to determine if removing visceral fat in mice genetically prone to developing colon cancer might prevent or lessen the development of these tumors.

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The researchers randomly assigned the mice to one of three groups. Mice in the first group underwent a sham surgery and were allowed to eat an unrestricted ?buffet style? diet, for the entirety of the study, which resulted in these mice becoming obese. Those in the second group were also provided an unrestricted diet and became obese, but they had their visceral fat surgically removed at the outset of the study. Mice in the third group also underwent a sham surgery, but were provided only 60% of the calories consumed by the other mice in order to reduce their visceral fat by dieting.

Overall survival
?Our sham-operated obese mice had the most visceral fat, developed the greatest number of intestinal tumors, and had the worst overall survival,? Huffman noted. ?However, mice that had less visceral fat, either by surgical removal or a calorie-restricted diet, had a reduction in the number of intestinal tumors. This was particularly remarkable in the case of our group where visceral fat was surgically removed, because these mice were still obese, they just had very little abdominal fat.?

The researchers then subdivided the groups by gender. In female mice, the removal of visceral fat was significantly related to a reduction in intestinal tumors, but calorie restriction was not. In male mice, calorie restriction had a significant effect on intestinal tumors, but removal of visceral fat did not.

?This suggests that there are important gender differences in how adiposity and nutrients interact with the tumor environment,? Huffman said. ?In addition, the study emphasizes the need to promote strategies that reduce visceral fat in abdominally obese individuals.?

Follow-up studies needed
Huffman noted that more studies are needed to definitively uncover the mechanisms behind the causality between visceral fat and intestinal cancer, to determine how abdominal obesity and nutrient availability act independently during the stages of tumor promotion and progression, and to determine how other strategies to promote weight loss, such as bariatric surgery, affect cancer risk.

For more information
Huffman DM, Augenlicht LH, Zhang X, Lofrese JJ, Atzmon G, Chamberland JP, Mantzoros CS. Abdominal Obesity, Independent from Caloric Intake, Accounts for the Development of Intestinal Tumors in Apc1638N/+ Female Mice. Cancer Prev Res March 2013 6; 177 doi: 10.1158/1940-6207.CAPR-12-0414

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