Macrophages are ?Big Eaters? Indeed | Marjolein van Egmond, Ph.D | Figure 2

Figure 2: Model of prevention of surgery-induced liver metastases development after mAb therapy.

Left: Resection of the primary colorectal cancer (upper picture) results in adherence of circulating tumor cells in the liver (middle picture). These will grow out as liver metastases (lower picture).

Right: Resection of the primary colorectal cancer (upper picture) results in adherence of circulating tumor cells in the liver, but these will be eliminated by Kupffer cells after pre-operative mAb therapy (middle picture). Consequently, the development of liver metastases is prevented (lower panel).

Article:

  • Macrophages are ?big eaters? indeed: Circulating tumor cells are devoured after monoclonal antibody therapy. [Article] M. Van Egmond, Ph.D. Department of Surgery and the Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands. doi: 10.14229/ONCO.2014.4.16.002

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