Lenalidomide Significantly Reduces the Risk of Smoldering Multiple Myeloma from Progressing

Annual Meeting of the American Society of Clinical Oncology at McCormick Place in Chicago, Ill.
Annual Meeting of the American Society of Clinical Oncology at McCormick Place in Chicago, Ill.

The phase II/III E3A06 randomized clinical trial (NCT01169337), funded by the National Institutes of Health (NIH), found that lenalidomide (Revlimid?; Celgene), significantly reduces the risk of smoldering multiple myeloma (SMM)* — an asymptomatic, precancerous, plasma-cell proliferative disorder — from progressing to cancer in patients at moderate or high-risk. Organ damage is typically seen in multiple myeloma, which is a way to differentiate it from SMM. [1]

The randomized trial showed that at three years, in 87% (phase II) and 91% (phase III) of people with SMM receiving lenalidomide, the condition did not progress to multiple myeloma compared with 66% of people who did not receive the therapy and were just observed for potential progression (phase III). Observation is the current standard of care.

The study results will be presented at the upcoming Annual Meeting of the American Society of Clinical Oncology (ASCO) held May 31 – June 4, 2019 in Chicago, Ill.

Anxious or Cautious

?We typically see two types of patients ? those who are anxious and want to do something to prevent cancer from developing, and those who are more cautious and are willing to watch and wait,? said lead study author Sagar Lonial, MD, Chief Medical Officer at Winship Cancer Institute of Emory University, Atlanta, GA.

?It?s gratifying to know that especially for the first group of patients there may now be a viable treatment option,? Lonial added.

Thalidomide analog

Lenalidomide is an analog of thalidomide, a therapy developed decades ago as a sedative. Lenalidomide prevents the formation of blood vessels that can feed tumors, such as those found in multiple myeloma, and it also carries the risk of serious side effects.

A recent study [2] looking at over 86,000 people with multiple myeloma found that 13.7% were first diagnosed as having SMM, with a median age of 67 at diagnosis. When extrapolated to multiple myeloma diagnosis data for the entire United States, this amounts to roughly 4,400 people in the United States being diagnosed with SMM each year.

In only half of people diagnosed with SMM, however, the condition progresses to multiple myeloma in the first five years. Once diagnosed with multiple myeloma, the 5-year survival rate is over 50%. Survival rates have steadily increased over the last decade thanks to the availability of several new therapies.[3]

Earlier this year, the American Society of Clinical Oncology included ?Identifying Strategies to Detect and Treat Premalignant Lesions? in its list of Research Priorities to Accelerate Progress Against Cancer. [4] The findings of this trial support this critical need and help provide a new preventive therapy for patients with this precancerous condition.

Trial Design
The E3A06 trial enrolled people with intermediate or high-risk SMM in two phases. In phase II, 44 people received lenalidomide to assess potential efficacy.

In phase III, investigators randomly assigned 182 people to a 25 mg pill of lenalidomide daily for 21 of the first 28 days of a therapy cycle, or observation, and stratified them based on whether they were diagnosed with high-risk SMM within that past year or more than a year after enrollment.?

In this trial, researchers used MRIs of the spine and pelvis to detect disease at enrollment, which is more sensitive than routine x-rays, which were used in previous studies exploring interventions for SMM.

Lenalidomide and dexamethasone

In a trial designed by the Spanish Myeloma Group demonstrated that the combination of lenalidomide and dexamethasone lengthened the time before people with SMM developed multiple myeloma and extended survival.[5]

Key Findings
In both the phase II and phase III trials, lenalidomide led to improved outcomes for patents with moderate and high-risk SMM.

  • Progression-free survival: In phase II, after 3 years on the trial, 87% of the enrollees were alive without SMM progressing to multiple myeloma (progression-free survival, defined as the time before myeloma develops). In phase III, after 1, 2, and 3 years on the trial, respective progression-free survival rates were 98%, 93%, and 91% for those who received lenalidomide and 89%, 76%, and 66%, respectively, for those who did not receive the treatment and were just observed.
  • Toxicity: The proportion of people who could not tolerate lenalidomide was concerning, with 80% of people in phase II and 51% of people in phase III discontinuing the medicine due to toxicity. The most common side effects, seen in 28% of patients, included fatigue and non-blood or bone related side-effects. High-grade neutropenia, which is a low count of neutrophils (a type of white blood cell), was seen in about 5% of people. There was no patient-reported difference in quality of life between those who took lenalidomide and those who did not.

According to the researchers, the combined positive results of this trial and the 2015 Spanish trial may support a change in clinical practice.

Follow Up
The investigators are currently performing an analysis of people who stopped taking lenalidomide due to toxicity to see if even limited doses of the medicine may have delayed progression to multiple myeloma.

Lonial noted that a major hallmark of this trial is that it shows that intervening early can prevent patients from developing organ damage, the current criteria by which patients are defined as having myeloma.

Commenting on the study and the study results Monica M. Bertagnolli, MD, FACS, FASCO, President of the American Society of Oncology, noted: ?Living with the uncertainty of whether cancer will develop is very difficult, so it?s exciting to be able to tell patients at high risk of multiple myeloma that they can take a pill to prevent or delay cancer.”

“However, this approach is not for everyone, however, because it comes with potentially heavy side effects and costs, so watching and waiting still has clear advantages that every patient should discuss with their doctor,? Bertagnolli concluded.

Phase II Progression Free Survival (PFS)
1 yr0.98
3 yr0.87
5 yr0.78
Phase III Progression Free Survival (PFS)LenalidomideObservation
1 yr0.980.89
2 yr0.930.76
3 yr0.910.66

Table description: E3A06 is a randomized phase III intergroup trial, testing the effect of single agent lenalidomide compared with observation for patients with intermediate or high risk smoldering multiple myeloma . In an initial phase II run in all patients received lenalidomide to demonstrate safety. Eligibility required ?10% plasma cell (PC) and abnormal serum involved/uninvolved free light chain (FLC) ratio (<0.26 or >1.65). The primary endpoint was progression free survival (PFS) estimated by the Kaplan-Meier method and compared using the one-sided stratified log-rank test. The Phase II trial enrolled 44 patients and Phase III randomized 182 patients to either lenalidomide (n=90) or obs (n=92). The results showed baseline characteristics to be similar between the arms. 80% (Phase II) and 51% (Phase III) are off lenalidomide, primarily due to adverse events (AE) or patient withdrawal.

Clinical Trial

Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma – NCT01169337

Reference

[1] Lonial S, Jacobus SJ, Weiss M, Kumar S, Orlowski RZ, Kaufman JL, et al. E3A06: Randomized phase III trial of lenalidomide versus observation alone in patients with asymptomatic high-risk smoldering multiple myeloma. J Clin Oncol 37, 2019 (suppl; abstr 8001) [Abstract]

[2] Ravindran A, Bartley AC, Holton SJ, Gonsalves WI, Kapoor P, Siddiqui MA, Hashmi SK, etc Prevalence, incidence and survival of smoldering multiple myeloma in the United States. Blood Cancer J.2016 Oct 21;6(10):e486. doi: 10.1038/bcj.2016.100. [Abstract]

[3] Cancer.Net Multiple Myeloma Statistics [Website]

[4] ASCO: Nine Research Priorities to Accelerate Progress Against Cancer. [Website]

[5] Mateos MV, Hern?ndez MT, Giraldo P, de la Rubia J, de Arriba F, L?pez Corral L, Rosi?ol L, Paiva B, et al. Lenalidomide plus dexamethasone for high-risk smoldering multiple myeloma. N Engl J Med. 2013 Aug 1;369(5):438-47. doi: 10.1056/NEJMoa1300439. [Abstract][Article]

*Smoldering Multiple Myeloma (SMM) is defined by the presence of a serum monoclonal (M) protein of ?3 g/dL and/or 10% to 60% clonal bone marrow PCs (BMPCs) with no evidence of end-organ damage (ie, CRAB criteria) or other MDE. It is distinguished from monoclonal gammopathy of undermined significance (MGUS) on the basis of the level of serum M protein and the percentage of clonal BMPCs