Spirogen, Ltd. is a clinical stage biotechnology company specializing in novel, sequence-selective, DNA minor groove-binding molecules with potent therapeutic properties. Spirogen’s principal technology involves modification of members of a group of naturally occurring antibiotics called pyrrolobenzodiazepines (PBDs). The company was founded in 2000, has 18 employees and is private equity funded. The company’s lead oncology drug candidate, SG2000, has completed solid tumour Phase I studies in the USA (through the NCI) and Europe (through Cancer Research UK).
Spirogen?s pipeline comprises two well characterized DNA minor-groove binding, interstrand cross-linking PBD dimer molecules, SG2000 and SG2285, plus a number of earlier stage leads. Additionally, the achiral duocarmycin analogue, AS-1-145 (Centanamycin), is now in pre-clinical development with the NCI.
A number of the company’s highly potent antineoplastic molecules are under development and?evaluation with pharmaceutical companies as candidates for development as part of antibody drug conjugate (ADC) therapies. Spirogen also has its own active program of ADC cytotoxic and linker development. The company works closely with ADC Therapeutics sarl in the development of its ADCs.
On October 15, 2013 AstraZeneca announced that MedImmune, its global biologics research and development arm, had acquired Spirogen. Today the company is a wholy-owned subsidiary of MedImmune.
Spirogen Ltd
The?QMB Innovation centre
London?E1 2AX
UK
Web: Spirogen, Ltd.
