This week Targovax, a clinical stage immuno-oncology company developing targeted immunotherapy treatments for cancer patients, announced that the first patient has been dosed in a phase Ib/II clinical trial evaluating ONCOS-102 for the treatment of malignant pleural mesothelioma (MPM), a rare type of cancer in the lining of the lung, in combination with pemetrexed and cisplatin.

ONCOS – 102 is a virus-based immunotherapy platform based on engineered oncolytic viruses armed with potent immune-stimulating transgenes targeting solid tumors. This treatment is designed to reactivate the immune system’s capacity to recognize and attack cancer cells.

New Therapy
“New therapies are needed to provide better care for patients with mesothelioma, a highly malignant cancer with poor prognosis” noted Magnus Jaderberg, MD, the Chief Medical Officer of Targovax.

“This clinical trial will provide data to evaluate the efficacy and safety of ONCOS-102 in first and second line mesothelioma patients, and we hope that our immunotherapy can provide additional benefit to chemotherapy, the existing standard of care,” Jaderberg observed.

“In addition, treating the first patient in the first oncolytic virus trial of the merged company is of course an exciting moment for Targovax and all its stakeholders,” Jaderberg added.

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Eligible for treatment with pemetrexed and cisplatin
The trial is a randomized phase I/II clinical trial of 30 patients, with a phase Ib safety lead-in cohort of six patients, in first lineand second line MPM patients who are eligible for treatment withpemetrexed and cisplatin. The trial’s main objectives are determinationof safety, immune activation at lesional level and in peripheral blood,clinical response and the correlation between clinical outcome and theimmunological activation. Several investigational sites in Europe willparticipate in this study. In addition to this trial, Targovax plans toinitiate three immunotherapy combination trials with ONCOS-102 and onewith its RAS peptide vaccine TG02 during the second half of 2016.

Asbestos exposure
Malignant mesothelioma is a rare type of cancer often caused by exposure to asbestos. There are no curative treatments although surgery, chemotherapy and radiotherapy can sometimes help to improve patient prognosis and life expectancy. Pemetrexed and cisplatin is the only standard of care chemotherapy for malignant mesothelioma, but the median PFS/OS (progression-free survival/overall survival) from the initiation of treatment is only approximately 12 months.

ONCOS-102 is a purposefully engineered human serotype 5/3 adenovirus coding for human GM-CSF optimized to induce systemic anti-tumor T cell response in cancer patients. In a previous Phase I trial, ONCOS-102treatment induced tumor specific immune activation both at systemic andlesional level. The immune activation was associated with clinical

Last editorial review: April 18, 2016.

Lung Cancer” from Stepan Popov

Featured Image:?Lung Cancer.? Courtesy: ? 2016 Fotolia/Stepan Popov. Used with permission.

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