Concortis Biosystems, Corp?is a biotechnology company creating next generation biotherapeutics using proprietary conjugation technologies and novel drug delivery systems, including antibody-drug conjugates (ADCs). ADCs are a new type of targeted therapy. They covalently connect potent cytotoxic drugs (referred as toxins) to an antibody or antibody fragment via chemical linkers, providing a means to increase the effectiveness of chemotherapy by targeting the drug to cancer cells while reducing side effects.?The antibody in use directs the ADC to bind to the target cancer cells, and then delivers the ADC to lysosome by receptor-mediated endocytosis, where the drugs are released to kill the cancer cells. The therapeutic index will be expanded because of the targeting effects
Linkers are designed to allow ADCs to remain inactive while in circulation, and should be readily cleavable once inside the target cells. Concortis’ miniPEG-based hydrophilic linkers help prevent the drug being pumped out of resistant cancer cells through MDR (multiple drug resistance) transporters.
Internalization and affinity of the mAb, linker stability, and potency of the cytotoxic are all key considerations when optimizing and developing an ADC. Over the past years, Concortis has developed diverse classes of cytotoxic drugs and linkers that are ready to empower therapeutic antibodies and to achieve synergistic effects.
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