Classification of Molecular Subtypes in Gastric Cancer

Stomach cancer falls into three broad subtypes that respond differently to currently available therapies. 

Using a technology called microarray-based gene expression profiling, researchers analyzed 248 gastric tumors, then further grouped them according to the genes that were expressed in the tumors. The gene expression analysis broadly sorts the tumors into three subtypes: proliferative, metabolic and mesenchymal. These subtypes also differ in their genomic and epigenomic properties. [Read Article]

For more information:
[1] Lei Z, Tan IB, Das K, Deng N, Zouridis H, Pattison S, Chua C, Feng Z, et al. Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil. Gastroenterology. 2013 Sep;145(3):554-65. doi: 10.1053/j.gastro.2013.05.010. Epub 2013 May 14.[Article][PubMed]
[2] NCT01231399 – Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal Cancer

Illustration Courtesy: Duke Medicine.

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