Since its discovery in the early 1990s, the protein?STAT1?(Signal Transducer and Activator of Transcription 1), is involved in upregulating genes due to a signal by either type I or type II interferons, and, as a results, are central in passing signals across immune cells, ensuring that our bodies react quickly and appropriately to threats from viruses or other pathogens. Animals without STAT1 are also prone to develop cancer, suggesting that STAT1 is somehow involved in protection against malignant cells. Click here to read more [Article]
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[1] Putz EM, Gotthardt D, Hoermann G, Csiszar A, Wirth S, Berger A, Straka E,et al. CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance. Cell Rep. 2013 Aug 15;4(3):437-44. doi: 10.1016/j.celrep.2013.07.012. Epub 2013 Aug 8.[Article][PubMed]
Illustration:?Inhibition of NK cells by phosphorylation of STAT1-Serin 727 mediated by CDK8.?Courtesy:?Eva-Maria Putz/Vetmeduni, Vienna, Austria.
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