The Almac Group provides a comprehensive range of services extending from research through pharmaceutical and clinical development to commercialisation of product. The company has significant experience in the manufacture of 14C-labelled Antibody Drug Conjugates (ADCs).
In recent years the interest in antibody drug conjugates for the targeted treatment of various cancer types has grown massively, and the need for evaluation of their pharmacokinetic profile is becoming more important. As a result the 14C labelling of ADCs for ADME evaluation has become a critical part of their development. The 14C label is typically placed on either the active drug or the linker moiety, or can be incorporated into both.
Almac?s expertise in this area comes from the integration of a number of diverse disciplines within the Isotope chemistry group. These disciplines include biology, chemistry, peptide and purification science, analytical and quality assurance. The ability to prepare labelled linkers and/or payloads, and to complete the bioconjugation within one team shortens timelines and results in a more cost effective solution for our clients.
20 Seagoe Industrial Estate
Craigavon BT63 5QD
United Kingdom
Web: Almac Group
